Purity Raw Bivalirudin Powder Bivalirudin

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Purity Raw Bivalirudin Powder Bivalirudin

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Product Description

📋 Basic Information

Product Name	Bivalirudin Powder
Certification	GMP, HSE, ISO 9001, USP, BP
CAS No.	128270-60-0
Molecular Formula	C98H138N24O33
Purity	>99% (HPLC)
Appearance	White Powder
Grade	Pharmaceutical Grade
Shelf Life	2 Years
State	Powder

🔬 Product Description

Bivalirudin is a synthetic 20 amino acid peptide direct thrombin inhibitor presented as a white to off-white lyophilized powder. It is highly soluble in water and in physiological saline solutions. The peptide sequence is H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH with a molecular weight of approximately 2180 Daltons.

Identity is confirmed by methods such as HPLC and peptide mapping using mass spectrometry. Purity is determined by reversed-phase HPLC, typically not less than 98.0 percent. Water content is strictly controlled via Karl Fischer titration (usually not more than 8.0 percent), and bacterial endotoxins are limited to ensure pharmaceutical safety.

🔍 Product Details

Product Name	Bivalirudin
Appearance	White Powder
CAS	128270-60-0
MF	C98H138N24O33
MW	2180.317

💡 Application & Function

✔

Bivalirudin functions as a direct and reversible inhibitor of thrombin, a key enzyme in the blood coagulation cascade. It specifically binds to both the active catalytic site and the substrate recognition exosite 1 of thrombin.

✔

It is indicated as an anticoagulant in adult patients undergoing percutaneous coronary intervention (PCI), including those with unstable angina or undergoing stent placement.

✔

It offers a predictable anticoagulant effect and a short half-life (approx. 25 minutes), reducing bleeding risks compared to other anticoagulants in certain clinical settings.

⚙ Technical Specification

❓ Frequently Asked Questions

Q1: What is the purity level of your Bivalirudin powder?

The purity of our Bivalirudin is typically ≥99% as determined by HPLC testing, meeting high pharmaceutical standards.

Q2: How should Bivalirudin lyophilized powder be stored?

It should be stored as a lyophilized powder at temperatures between 2 to 25 degrees Celsius. Reconstituted solutions should be used immediately.

Q3: What are the primary medical applications?

It is primarily used as an anticoagulant for adults undergoing percutaneous coronary intervention (PCI), especially for those at risk of heparin-induced thrombocytopenia (HIT).

Q4: What is the molecular weight and sequence type?

It is a synthetic 20 amino acid peptide with a molecular weight of approximately 2180 Daltons.

Q5: What is the shelf life of the product?

The product has a shelf life of 2 years when stored under proper conditions in its original packaging.

Q6: Why is Bivalirudin sometimes preferred over heparin?

Bivalirudin offers a more predictable anticoagulant response, a shorter half-life, and is associated with lower rates of major bleeding in certain patient populations during coronary procedures.